Scientist III
1000 Gateway Blvd. South San Francisco, CA 94080 US
Job Description
Target PR Range: 63-73/hr
*Depending on experience
Precision Medicine Pathology
The Precision Medicine Pathology team drives the scientific strategy for translational tissue-based biomarker development & discovery target validation/MOA projects, leads pathology collaborative programs, conducts histopathological evaluation & analysis of IHC & other tissue-based studies, and provides technical/scientific leadership to histotechnicians & pathology scientists.
In this role, you will be supporting a variety of studies using multiplex immunofluorescence assays. You must be able to conceive and implement multiplex IF assays to answer scientific questions.
Responsibilities:
· Designing, developing and validating multiplex immunofluorescence panels using OPAL or similar technologies.
o Designing an mIF panel with consideration of biologic & technical factors
o Developing & optimizing the mIF panel
o Scanning mIF slides using PhenoImager HT
o Spectral unmixing using inForm
· Digital pathology analysis using Halo or VisioPharm
· Expected to make significant contributions to project team through lab-based activities
· Highly autonomous and productive in performing laboratory research or method development
· Formulate conclusions and design follow-on experiments based on multidisciplinary data
Qualifications:
· Bachelor’s Degree in Science related field with 5+ years of related work; Master’s Degree Science with 10+ years of related work.
· Close familiarity with the principles of tissue microscopic anatomy/histology including knowledge of pathological alterations in disease and experience working in collaboration with trained pathologists is preferred.
· Extended experience in designing, developing & validating multiplex mIF assays using OPAL or similar technologies, as well as scanning the mIGF stained slides & spectral unmixing using inForm.
· Experience in digital image analysis using Halo or VisioPharm.
· Excellent verbal communication skills are required including the demonstrated ability to effectively and clearly summarize results for presentation and report generation
· Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment
· Ability to multi-task and manage multiple projects
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