Associate Director of Early Research
280 UTAH AVE., SUITE 200 SOUTH SAN FRANCISCO, CA 94080 US
We are using the emerging tools of genetic medicine to engineer cures for human diseases. We believe these powerful new approaches can be used to treat, or cure, common diseases that afflict large numbers of patients. To realize this vision, we are building therapeutics that modify and control multiple genes at the DNA, RNA, and protein level in vivo. We have a vibrant, collaborative workplace that supports our team in performing great science while bringing their whole selves to work. We are seeking several highly motivated, creative individuals to join our growing team.
About the Role:
As an Associate Director of Early Research, you will advance our genetic medicine technologies, enabling the discovery and development of new therapeutics. Working with a diverse team of cell biologists, protein and RNA engineers, computational scientists, molecular biologists, and translational biologists, you will:
- Build improved CRISPR-Cas-related and novel systems that enable therapeutic genome and transcriptome engineering
- Identify specific genomic targets and develop candidate strategies for therapeutic intervention using our technology portfolio
- Comprehensively characterize the genotypic changes induced by candidate therapies, including efficacy, specificity, oncogenic potential, etc.
- Assess the functional impact of therapeutic candidates using appropriate in vitro and in vivo model systems
- Develop in vivo delivery approaches for candidate therapies using AAV, LNP, or other platforms
- Support IND-enabling studies including toxicology, CMC, immunology, and related
- Maintain comprehensive, accurate records to support scientific best practices, diligence, IND submissions, etc.
- Mentor and manage junior scientists/associates by leading discussions of new ideas and/or approaches, challenging ideas and interpretations, and cultivating teams to help solve challenging experimental questions
- A PhD in a biological discipline, with a minimum of eight years of experience focused on bioengineering to change the behavior of cells through control of the genome or transcriptome
- Demonstrated leadership experience, including managing both dynamic project teams and direct reports
- Excellent communication skills and experience working with company leadership to influence strategy and longer-term planning
- A creative thinker with a track record of high-quality data generation
- An experimentalist ready and able to drive to the full cycle of design/build/test/analyze
- Strong understanding of cell engineering and tissue culture best practices
- Demonstrated track record of characterizing, developing, and optimizing genome or transcriptome modification systems
- Experience using CRISPR-Cas or similar gene editing tools for therapeutic applications
- Experience with therapeutic target selection and optimization
- Experience engineering protein-DNA and/or protein-RNA interactions
- Demonstrated ability to work in multi-disciplinary teams to achieve experimental objectives
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