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Associate Scientist - Research Scientist, Neuroscience

New Haven, CT 06511

Posted: 06/12/2024 Employment Type: Contract Job Category: Scientific Job Number: 607582 Is job remote?: No Country: United States

Job Description

Position Summary:
This is an exciting opportunity to join our growing Neuroscience team. As client's portfolio of preclinical and clinical programs continues to expand, the candidate for this postion will have a tremendous opportunity to help us drive our translational strategy for current and upcoming clinical stage neuroscience PROTAC drug candidates. We are seeking a highly motivated and collaborative candidate who is passionate about advancing novel  neurodegeneration therapies for a laboratory-based position.  This individual will have strong experimental skills and will utilize a variety of techniques to profile pharmacokinetic-phamacodynamic properties and downstream functional mechanisms of PROTAC drug candidates.
This position reports to a Senior Director, Neuroscience and will be located at our headquarters in New Haven, CT.

Principal Responsibilities:
As part of the Neuroscience team, the candidate will assist in the assessment of target engagement, pathway engagement and evaluation of pharmacokinetic and pharmacodynamic (PK/PD) relationships as part of ongoing preclinical research studies across multiple programs. Key responsibilities of this role include, but are not limited to:
  • Independently design and execute experiments, and perform data analysis
  • Leverage multiple assay platforms to assess mechanisms/pathways associated with PROTAC degrader molecules
  • Interact and collaborate with neuroscience, chemistry, translational and clinical team members to contribute to drug discovery and development program progression
  • Document, compile and interpret experimental data; manage electronic laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
  • Keep up-to-date on relevant scientific literature
Qualifications:
  • Cell culture (cell lines, iPSC-derived neurons, primary neurons); including cell line maintenance, transfection, and compound treatment
  • Ex vivo and/or clinical sample handling and processing for protein extraction and detection
  • Proficient in molecular and cellular biology techniques and biochemical assays, including but not limited to immunoblotting, ELISA, and MSD
  • Biomarker expierence is a plus
  • Plate-based assay development and validation experience is desirable
  • Innovative and creative individual with the ability to work independently and in a team environment, prioritize experimental design and data analysis, and take ownership of multiple projects
  • Well organized and demonstrated ability to prepare technical reports, summaries, protocols,etc.
  • Highly motivated with strong interpersonal and communication skills
Education:
  • MS in biological sciences with a minimum of 5 years of related experience; previous industry experience is a plus.
  • Neuroscience background or understanding is preferred but not required
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