Associate Scientist II
675 West Kendall Street Cambridge, MA 02142 US
Job Description
Overview:
The successful candidate will be a part of the Process Chemistry group, responsible for the process development and in-house non-GMP manufacture of modified oligonucleotides and siRNAs.
Summary of Key Responsibilities:
- Support non-GMP oligonucleotide production on a tight timeline
- Support purification method development, optimization, and scale-up
- Execute non-GMP oligonucleotide purifications
- Execute downstream processing of purified material
- Execute in-process analytical tests
- Participate in creating and reviewing SOPs and batch records
- Support campaign activities across other unit operations as-needed
Qualifications:
- BS in Chemistry with 1-3 years lab experience, preferably in an industrial setting.
- Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred. Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.
- Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance.
- Good communication skill is a must for this position. The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.
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