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Bioinformatics Analyst II

Cambridge, MA 02139

Posted: 10/08/2024 Employment Type: Contract Job Category: Scientific Job Number: 614715 Is job remote?: No Country: United States

Job Description


Target PR Range: 32-42/hr
*Depending on experience

Position Overview:

Systems Immunology and Immune Profiling center (SI/IPC) team in Cambridge, Massachusetts is seeking a highly skilled contractor with expertise in bioinformatics and computational biology, with a strong emphasis on proteomics analysis, including Cytometry by Time Of Flight (CyTOF), Imaging Mass Cytometry (IMC) and Mass Spectrometry (MS). The successful candidate will play a critical role in analyzing internal datasets and advancing our mission to identify novel therapeutic targets for autoimmune and chronic inflammatory diseases.

Key Responsibilities:

· Perform advanced analysis of high-dimensional proteomics data, including CyTOF, Flow Cytometry, and MS, to generate actionable insights into disease mechanisms.

· Help develop and optimize computational workflows and pipelines for processing, analyzing, and interpreting proteomics datasets.

· Perform image-based quantification of proteins using IMC, focusing on spatial distribution and co-localization of immune cells and other tissue components in situ.

· Collaborate with multidisciplinary teams, including immunologists, data scientists, and biologists, to interpret proteomics data and translate findings into preclinical and clinical research applications.

· Present complex analytical approaches and results to both technical and non-technical stakeholders, effectively communicating the scientific rationale and implications.

Skills and Qualifications:

- Education:

M.S. in bioinformatics, computational biology, proteomics, biochemistry, or a related field.

- Technical Expertise:

· Proficiency in programming languages such as R and Python, and experience working in Unix/Linux environments.

· Knowledge of statistical methods and machine learning techniques applicable to the analysis of large-scale proteomics datasets.

- Preferred Skills:

· Experience with computational methods for protein quantification, identification of post-translational modifications, and protein-protein interaction network analysis.

· Familiarity with CyTOF, spatial CyTOF (IMC), and Flow Cytometry data analysis techniques is desirable.

· Expertise in proteomics data analysis, including Mass Spectrometry (MS)-based proteomics, and familiarity with related software tools or other proteomics data analysis platforms.

· Strong communication skills with the ability to present complex data to both scientific and non-scientific audiences.

· A proactive and collaborative approach to problem-solving in a dynamic, fast-paced research environment.

· Ability to manage multiple projects simultaneously and adapt to changing priorities.

· Contribute to the preparation of scientific publications, presentations for conferences, and regulatory submissions (if any).

- Key Competencies:

· Demonstrated ability to work independently while contributing effectively to multidisciplinary teams.

· Organizational skills with the capacity to manage competing priorities and deliver high-quality work within deadlines.

· Commitment to continuous learning, innovation, and staying current with the latest developments in proteomics and computational biology.
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