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Biologist III

Worcester, MA 01605

Posted: 05/11/2024 Employment Type: Contract Job Category: Scientific Job Number: 606590 Is job remote?: No Country: United States

Job Description


Target PR Range: 38-48/hr
*Depending one experience

The scientist in this position will have several responsibilities in supporting CHO biologics pipeline, including genetic characterization of cell lines and cell banks. A strong candidate will have in-depth experience with a variety of molecular biology techniques and mammalian cell culture/aseptic technique, as well as exceptional attention to detail, demonstrated skills and productivity in laboratory research, and strong writing and communication skills.

Key Responsibilities:
· Characterize CHO cell lines using molecular biology techniques, including qPCR, ddPCR, Southern blot, and northern blot
· Sanger sequencing analysis
· Design of primer/probe reagents for gene copy number analysis
· Use of gel and blot imaging instruments
· Maintain detailed, accurate, and clear documentation of experiments and activities
· Effectively organize and communicate research progress and planned activities through oral and written presentations
· Collaborate with colleagues in the Cell Line Development group and across multiple functional areas of the Bioprocess Development and Launch department to advance the company Biologics Pipeline
· Maintain a high level of productivity in the lab
· Demonstrate scientific initiative and creative thinking to achieve project goals and contribute team performance in a climate of scientific rigor
· Contribute to the smooth and effective operation of the CHO Cell Line Development labs through the 5S program
· Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, and GxP compliance

Qualifications:
· Bachelor’s Degree or Master’s Degree in Cell/Molecular Biology or a related field with 5 years of relevant experience; pharmaceutical industry experience is preferred
· Expertise in molecular biology techniques, including DNA/RNA extraction and quantification, PCR-based assays, gel electrophoresis, blotting techniques and sequencing analysis
· Hands-on experience with mammalian cell culture
· Experience with DNA sequence manipulation software and common software packages such as Microsoft Office
· Excellent written and interpersonal communication skills with the ability to build strong relationships with peers and cross-functional team members
· Strong planning, multitasking, time management, and troubleshooting skills
· Collaborative and proactive attitude with strong scientific curiosity, work ethic, and attention to detail
· Authorization to work in the United States is required

Preferred Qualifications:
· Experience with expression vector elements, construction, and molecular cloning
· Experience with digital PCR assays, such as droplet digital PCR (ddPCR)
· Proven track record in vector biology, cell line genetic characterization, and/or CHO cell line development
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