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Biologist III

Worcester, MA 01605

Posted: 01/09/2025 Employment Type: Contract Job Category: Scientific Job Number: 616541 Is job remote?: No Country: United States

Job Description


Target PR Range: 37-47hr
*Depending on experience

The Bioprocess Development Department at the Bioresearch Center is seeking a highly motivated Contract Scientist to work with us on several CHO Cell Line Development team projects. The selected candidate will join the teams working on a new cell line development platform based on “targeted integration”, as well as other process optimization and cell line characterization studies. A strong candidate will have in-depth experience in mammalian cell culture/aseptic technique, exceptional attention to detail, demonstrated skills and productivity in laboratory research, and strong communication skills. Ideally the candidate will also have experience in one or more of the following: biopharmaceutical industry, recombinant cell line development (transfection, selection, cloning), genetic engineering (e.g., CRISPR Knock-Out/Knock-Ins, Cre/Lox), flow cytometry/FACS, recombinant protein production, and/or related skills.

Responsibilities:
• Maintain a high level of productivity in the lab, with clear and accurate documentation
o Develop and characterize CHO (Chines Hamster Ovary) cell lines within project timelines using both established and novel techniques; o Optimize methods as required to meet project goals;
o Extensive cell culture work as needed to generate, maintain, evaluate, and preserve many suspension cell lines in parallel;
• Work both independently and as a member of collaborative teams; • Effectively utilize standard software (e.g., Microsoft Excel, Word, PowerPoint, Electronic Lab notebook applications)
• Understand and adhere to corporate standards regarding code of conduct, documentation, safety, appropriate handling of materials, and GxP compliance.

Requirements:
• Bachelors or Masters degree in Biological Sciences with relevant laboratory experience.
• Must be currently authorized to work in the U.S. for at least one year after position start date
• Must be able to sit or stand for extended times in the laboratory
• Proven track record in one or more of the following: cell culture/aseptic technique, cell line development, CHO cells, genetic engineering (e.g., CRISPR knock-out/knock-in, homologous recombination, targeted integration, cre/lox, frt/flp); flow cytometry/FACS; genetic characterization (e.g. ddPCR, qPCR, NGS), expression vector design.
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