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Cell Engineering Scientist

SOUTH SAN FRANCISCO, CA 94080

Posted: 02/28/2024 Employment Type: Direct Hire/Perm Job Category: Engineering Job Number: 599730 Is job remote?: No Country: United States

Job Description

As a Cell Engineering Scientist, you will advance our genetic medicine technologies, enabling the discovery and development of new therapeutics. Working with a diverse team of cell biologists, protein and RNA engineers, computational scientists, molecular biologists, and translational biologists, you will:
  • Build improved CRISPR-Cas-related and novel systems that enable therapeutic genome and transcriptome engineering
  • Identify specific genomic targets and develop candidate strategies for therapeutic intervention using our technology portfolio       
  • Comprehensively characterize the genotypic changes induced by candidate therapies, including efficacy, specificity, oncogenic potential, etc.
  • Assess the functional impact of therapeutic candidates using appropriate in vitro and in vivo model systems
  • Develop in vivo delivery approaches for candidate therapies using AAV, LNP, or other platforms
  • Support IND-enabling studies including toxicology, CMC, immunology, and related
  • Maintain comprehensive, accurate records to support scientific best practices, diligence, IND submissions, etc.  
  • Mentor and manage junior scientists/associates by leading discussions of new ideas and/or approaches, challenging ideas and interpretations, and cultivating teams to help solve challenging experimental questions

Requirements:
  • A PhD in a biological discipline, or a masters with a minimum of four years of experience in independent experimental design, focused on bioengineering to change the behavior of cells through control of the genome or transcriptome
  • A creative thinker with a track record of high-quality data generation
  • An experimentalist ready and able to drive to the full cycle of design/build/test/analyze
  • Strong understanding of cell engineering and tissue culture best practices


Preferred Qualifications:
  • Demonstrated track record of characterizing, developing, and optimizing genome or transcriptome modification systems
  • Experience using CRISPR-Cas or similar gene editing tools for therapeutic applications
  • Experience with therapeutic target selection and optimization 
  • Experience engineering protein-DNA and/or protein-RNA interactions
  • Experience establishing pooled or other high throughput screens
  • Demonstrated ability to work in multi-disciplinary teams to achieve experimental objectives
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