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Head of Translational Medicine

South San Francisco, CA 94080

Posted: 11/01/2022 Employment Type: Direct Hire/Perm Job Category: Scientific Job Number: 329348 Pay Rate: 245,000 Is job remote?: No Country: United States

Job Description

Our client is a well funded start-up using human genomics to accelerate development of treatments for neurodegenerative diseases. The approach our client is taking is a true breakthrough opportunity using human genetics and machine learning to identify drugs that can drastically improve patient outcomes AND lower the drug development cost.

Title: Head of Translational Medicine
Responsible for developing early clinical strategy and overseeing the execution of Phase 1 trials, including the establishment of clinical infrastructure and key relationships. You will also drive the selection of clinical biomarkers for target engagement, patient selection, and signs of efficacy leveraging the unique insights gained from the proprietary genomics platform.  What You'll Do:
  • Develop and execute an innovative translational medicine and biomarker strategy
  • Demonstrate utility/validation of markers in clinical studies, oversee the assay/method development and patient sample acquisition, assess the natural history of the marker in relevant patient samples/populations, and assess inter- and intra-patient variability 
  • Oversee pre-clinical studies demonstrating a drug effect on the marker by confirming response of the marker to drugs in animal models and cellular assays, and acquiring translational data required to guide the design of clinical studies
  • Design and oversee the use of biomarkers in clinical studies, writing protocols for incorporation of biomarkers in clinical trials, training trial sites or clinical CROs to ensure protocols are followed, overseeing the analysis of markers in clinical samples, and preparing reports suitable for regulatory documents
  • Lead planning and preparation for Phase I, and Phase IIa/b clinical trials
  • Oversees the execution of Phase 1 trials, including selection of the clinical trial sites, analysis of the trial data, and preparation of regulatory documents 
  • Serve as a strong external face of the company to form key connections with the disease community, clinical KOLs, and other partners necessary for a successful clinical trial
Perks & Benefits
  • Medical, dental, and vision insurance
  • Healthcare FSA
  • Short- and long-term disability insurance
  • Life insurance
  • 401k 
  • Company equity
  • Unlimited PTO
  • Free lunch and snacks onsite
  • Free on-site gym access (currently restricted due to COVID)

 

The staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.

Planet Pharma and The Planet Group of Companies are equal opportunity employers. It is our practice not to discriminate against any employee or applicant based on any criteria, condition or basis protected by laws or regulations in the locations where we do business. All qualified applicants are encouraged to apply. We celebrate diversity and are committed to providing an environment of mutual respect. We believe that diversity, equity and inclusion enable us to better meet our mission and values while serving our clients across the globe. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter, or contact us, so that we can discuss the appropriate alternatives available.

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About South San Francisco, CA

Ready to take the next step in your career journey? Explore our job opportunities in the vibrant area surrounding South San Francisco, California! Known for its proximity to the iconic Golden Gate Bridge and the bustling tech hub of Silicon Valley, this region offers unrivaled growth potential and a dynamic work environment. With a unique blend of culture, including the renowned SFMOMA art museum, the lively Castro District, and delectable cuisine like the famous sourdough bread at Boudin Bakery, South San Francisco is the perfect place to thrive professionally while enjoying the beauty of nearby parks like Golden Gate Park and the breathtaking views of the Pacific Ocean. Join us in discovering the endless possibilities for your career in this enchanting region!

Although this hasn't been an issue at Planet Pharma, the staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.