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Principal Scientist, Protein Production & Process Development
One Kendall Square Cambridge, MA 02139 US
Job Description
Role Overview
We are seeking an experienced Protein Production and Process Development leader with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research associates and scientists focused on production of lead TCR bispecific molecules and optimization of processes. The selected candidate and his/her/their team will work in a highly dynamic and cross-functional environment to facilitate seamless technology transfer to an external contract development and manufacturing organization (CDMO). The incumbent will also enable Repertoire’s proprietary platform technologies with high quality pMHC products produced by microbial or mammalian systems. The incumbent will interface with internal preclinical Immunology, Protein Modality, and DECODE platform teams, as well as the internal CMC Leader, to provide protein reagents and protein leads, including data packages supporting Development Candidate nomination.
Key Responsibilities
Develop and optimize upstream and downstream processes to generate lead and Development Candidate TCR bispecific and to enable seamless technology transfer to contract manufacturing organizations.
Provide data packages, expertise, and guidance to TCR bispecific candidate nomination decision.
Transfer analytical methods to external CROs/CDMOs and provide additional training, troubleshooting, or technical support, as necessary.
Manage technology development and production of novel pMHC reagents to enable target identification, target validation and TCR affinity maturation for both oncology and/or autoimmune indications.
Drive team engagement, ownership, and agility to deliver ambitious results.
Author and review technical documents and reports for inclusion in CMC sections of regulatory filings.
Qualifications/Experience
- Academic/PhD degree in Biochemistry, Biology, Bioengineering, Immunology, or related discipline.
- Proven experience leading and managing lab teams within complex programs to drive functional and corporate goals.
- Minimum 8+ years’ experience in pharma/biotech industry with management experience in process development.
- Production experience with proteins expressed and refolded from E. coli and with proteins expressed in mammalian cells with oversight of both upstream and downstream process development.
- Experience in research strategy development and operational management of research outcomes through cross-functional and outsourced teams, as well as budget planning and management.
- Technical report writing for inclusion in regulatory submissions.
- Desirable to have experience with bispecific protein products.
- Ability to drive strategic discussions with senior level management and external partners.
- Experience in building practical creativity in teams to persist and respond positively to changes.
- Experience in collaborating across teams to resolve problems with strategic and operational impact on individual, function, and corporate performance.
Equal Opportunity Employer: We are proud to be an equal opportunity employer. We welcome and encourage applications from all qualified candidates regardless of race, sex, gender identity or expression, disability, age, religion or belief, sexual orientation, or any other characteristic protected by applicable laws and regulations. It is our policy not to discriminate against any applicant or employee, and we are committed to fostering a diverse, inclusive, and respectful work environment across all locations in which we operate. We believe that diversity, equity, and inclusion are fundamental to our mission and enhance our ability to serve clients globally. If you have a disability or require any reasonable accommodations during the application or interview process, please inform your recruiter or contact us directly so that we can explore the appropriate arrangements.
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