Skip to content

Job Openings

Process Chemist

Cambridge, MA 02139

Posted: 01/08/2025 Employment Type: Contract Job Category: Scientific Job Number: 616467 Is job remote?: No Country: United States

Job Description

LOOKING FOR:
Lab experience / actively in lab-oriented position/ full time lab person
Process chem experience
Extensive synthetic chemistry experience
prior experience in scale-up and process intensification.
Process validation experience
a person who is adept at synthesizing small molecules using standard organic synthesis techniques to construct these molecules in a large scale environment.
A person who will be in the lab cranking out results to optimize a small molecule process to be registration-ready

Here is also specific feedback on why he liked a certain candidate:

a.    Solid background in organic chemistry (PhD with a reputable advisor in the field in Marc Snapper) and a BS at WPI (a solid school) is a plus. 
b.    He has worked in the industry for about 10 years which is the right amount of experience we are looking for.
c.    Has done scale up. Made close to 500 g of a compound and worked on several multi-step synthesis projects.
d.    Produced reports for FDA IND filings and done some impurity identification.


This is a biopharmaceutical company focused on providing medicines for some of the world’s most challenging diseases. We’re committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with genetically defined diseases (GDD), encompassing both rare and more common diseases, and mining the extensive potential in the PK platform. We are leading the way in advancing PKR activation for hemolytic anemias, including pyruvate kinase (PK) deficiency, thalassemia and sickle cell disease, and have demonstrated a strong commitment to these patient communities. We continue to foster a productive research engine that yields new insights and potential therapeutic approaches. We’re a company that cares about our work, each other, and the people who are counting on us the most. We’re inspired to think big and welcome the different perspectives and backgrounds needed to deliver extraordinary results. We’re driven to be our best selves, together, so we can reach for the Other Side of Possible.

This team is searching for a dynamic Contractor Process Chemist to join the growing Process Research and Development team. The Senior Scientist / Principal Scientist will be able to follow programs as they proceed through development as supporting the overall drug substance development and manufacturing activities.  The successful candidate needs to demonstrate a proven track record of solving technical challenges while supporting GMP manufacturing. 

Key Responsibilities
  • Solve technical issues related to drug substance manufacturing by providing hands-on laboratory support within the chemical development group including process design, optimization, scale-up, process intensification, process characterization, and spike-and-purge studies to bring a clinical phase program to commercial readiness.
  • Work with external CMO/CRO teams to enhance/support their laboratory experimentation
  • Author internal technical reports based on in-house laboratory research and provide critical review of similar reports generated at external CMO/CROs
  • Identify key knowledge gaps and execute plans to ensure process understanding is commensurate with a given program’s stage of clinical development

Minimum Requirements
  • In-depth knowledge of synthetic organic chemistry
  • MS or PhD in organic chemistry with 5+ years (MS) or 3+ years (PhD) of industry experience
  • Demonstrated laboratory experience developing processes to produce small molecule pharmaceuticals from early to late-stage development
  • Ability to navigate and be successful in a fast-paced, highly-matrixed work environment
  • Effective verbal and written communication skills
  • Demonstrated experience with organic chemistry instrumentation and interpretation including HPLC, LCMS, GC, NMR and applicable software (ChemDraw, Excel, Word, Powerpoint).
  • Demonstrated proficiency to manage timelines by effective prioritization to meet project goals

Preferred Qualifications
  • Working knowledge with DSC, TGA, and XRPD instrumentation and familiarity with Mettler?Toledo equipment are preferred.
  • Demonstrated scientific contribution to the synthetic community evidenced by presentations and publications
  • Regulatory writing experience including IND/IMPD/NDA/MAA drug substance quality modules.


 

The staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.

Planet Pharma is an equal opportunity employer. It is our practice not to discriminate against any employee or applicant based on any criteria, condition or basis protected by laws or regulations in the locations where we do business. All qualified applicants are encouraged to apply. We celebrate diversity and are committed to providing an environment of mutual respect. We believe that diversity, equity and inclusion enable us to better meet our mission and values while serving our clients across the globe. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter, or contact us, so that we can discuss the appropriate alternatives available.

Apply Online

Send an email reminder to:

Share This Job:

Related Jobs:

Login to save this search and get notified of similar positions.

About Cambridge, MA

Calling all job seekers! Discover exciting job opportunities in and around Cambridge, Massachusetts, a vibrant city known for its rich history, world-renowned universities like Harvard and MIT, and innovative tech scene. Cambridge offers a unique blend of academic excellence, cultural diversity, and a thriving arts community, with attractions like the iconic Harvard Square, the charming Charles River Esplanade, and the prestigious American Repertory Theater. From savoring local specialties like clam chowder and lobster rolls to cheering on the Red Sox at Fenway Park, there's something for everyone in this dynamic region. Explore job listings today and kick-start your career in this captivating area!

Although this hasn't been an issue at Planet Pharma, the staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.