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Research Associate II - Cancer Target and Technology, Discovery Biology

Redwood City, CA 94063

Posted: 04/08/2024 Employment Type: Contract Job Category: Scientific Job Number: 603911 Is job remote?: No Country: United States

Job Description

The Opportunity:  Research Associate II - Cancer Target and Technology, Discovery Biology

Our client is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value targets in RAS-addicted cancers with our novel tricomplex inhibitor platform. We seek a highly enthusiastic Research Associate II to help the Discovery Biology team advance our discovery and development pipeline.  The successful candidate will join a high-functioning team of chemical biologists, biochemists, and cell biologists to help identify new molecules of interest, characterize compounds with novel mechanisms of action, and identify new potential targets. They will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting cellular assay. The ideal candidate is an open-minded and enthusiastic team player who enjoys problem-solving and has an eagerness to learn and implement new techniques.

The responsibilities may include:

  • Develop and conduct mechanistic cellular assays to characterize novel hit compounds.

  • Design and conduct in vitro cellular assays (e.g. mammalian cell culture, Lentiviral Transduction, 2D and 3D cell culture, SDS-PAGE/Western blot, qPCR, CRISPR-based gene editing) and implement relevant assay readout technologies (e.g. Luciferase, CellTiter-Glo, TR-FRET/BRET, MSD).

  • Maintain detailed and organized records of protocols and experimental results.

  • Collaborate cross-functionally with other team members to advance projects.

  • Analyze, interpret, and present experimental data in team meetings.

Required Education, Experience, and Skills:

  • BS with 2+ years of experience or MS in Molecular/ Cell Biology, Cancer Biology or Chemical Biology.

  • Extensive experience in aseptic technique, cell culture techniques, media preparation and maintenance of mammalian cell cultures, and cryopreservation of cells.

  • Experience in microplate-based assay systems and operation of plate readers or microscopes.

  • Rigorous, detail-oriented, quantitative experimentalist keen to maximize efficiency.

  • Highly organized, with excellent record-keeping, problem-solving, and written/verbal communication skills.

Preferred Skills, Experience and Education:

  • Familiarity with data processing and visualization tools for data analysis (e.g., GraphPad Prism, Genedata Screener, R, etc.) is preferred

  • Experience with automated liquid handling systems and workflows is a bonus

  • Familiarity with the following cellular and biochemical readouts, including immunofluorescence, luminescence, cell viability, FRET, ELISA, MSD, flow cytometry, is a bonus
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