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Research Associate

Cambridge, MA 02139

Posted: 06/21/2024 Employment Type: Contract Job Category: Scientific Job Number: 607266 Is job remote?: No Country: United States

Job Description

How will your role help us transform hope into reality? This position offers the opportunity to impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment. We are searching for a dynamic Associate Biology Scientist with experience interrogating cellular and molecular mechanisms as they relate to kinase target pathway modulation, off-target liabilities, and resistance.   What will you do?
  • Independently, develop, optimize, and proactively troubleshoot cellular screening assays.
  • Responsible for generating, processing, interpreting, and presenting data in cross functional team meetings
  • Proactively employ cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action.
  • Independently design, execute and document experiments to evaluate target dependency, off target liabilities, phenotypic responses and identifying resistance mechanisms.
  • Regularly share and present data with team members.
  What minimum qualifications do we require?
  • MS/BS in oncology, cellular biology, molecular biology, or related discipline with 1+ years of industry or relevant research experience is required.
  What additional qualifications will make you a stronger candidate?
  • Experience in developing and optimizing cell-based assays in multiple platforms (for example CTG, HTRF, AlphaLISA, FC, Jess-WB, NanoBret, Nanostring).
  • Experience with different molecular and cellular biology techniques (such as Western Blot).
  • Experience with genome editing (CRISPR or si/shRNA) for engineering cell line models is a plus.
  • Familiar with tumor models and establishing PK/PD/efficacy relationships and delivering PD readouts by western blots for in vivo tumor models.
  • Experience with standard software analytical tools, xlsx, Prism, or other synergy software.
  • Strong oral and written communication skills, as well as excellent documentation and organizational skills.
  • A team player, who listens effectively, invites response and discussion.
  • Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism
 
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