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Research Associate/Senior Research Associate - Assay Technologies, Lead Discovery

Redwood City, CA 94063

Posted: 09/19/2023 Employment Type: Contract Job Category: Scientific Job Number: 586488 Is job remote?: No Country: United States

Job Description

Our Client is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for an experienced Research Associate/Senior Research Associate to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of biochemical, biophysical, and cell screening techniques to drive the efficient identification and rapid development of clinically impactful drugs against frontier targets in oncology. Working from the bench, they will apply their biochemical and biophysical expertise. The candidate will support Discovery Science efforts to enhance how we discover inhibitors of established and new drug target proteins, as well as contribute to our mission of providing high-quality experimental data for existing programs.

Required Experience, Skills, and Education: 

  • Bachelor’s degree with 2-5 years of experience or Master’s degree with 0-3 years of experience in biochemistry, biophysics, biotechnology, or related field.

  • Experience with protein characterization (intact mass and/or peptide mapping) using an LCMS system including sample preparation, instrument operation, and data analysis.

  • Proficient in execution of in vitro biochemical and biophysical assays suitable for the discovery, validation, or mechanistic characterization of target molecules (SPR, BLI, ITC, TR-FRET, fluorescence polarization, etc.).

  • Excellent written and verbal communication skills.

  • Innovative, team-player with high energy and a demonstrated willingness to learn in a fast-paced environment.

Additional Desired Skills:

  • Familiarity with either an Agilent QTOF or Waters QTOF instrument.

  • Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito, Agilent Bravo, Tecan).

  • Familiarity with data processing and visualization tools to analyze large datasets (e.g., Genedata Screener and/or Expressionist, Vortex, KNIME, Spotfire).

  • Facile with instrumentation, able to trouble shoot problems and work with engineers to generate successful solutions to technical limitations.

  • Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.

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