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Scientist, Formulation Development

Menlo Park, CA 94025

Posted: 08/17/2022 Employment Type: Direct Hire/Perm Job Category: Scientific Job Number: 341454 Is job remote?: No Country: United States

Job Description


The incumbent will be responsible for development and optimization of formulation for lipid nanoparticle / RNA-based product candidates for preclinical and clinical development. In this role the candidate will work with cross-functional product development team including process development and analytical development to develop formulations with a good safety profile and high potency in vitro and in vivo.

 

HERE’ S SOME OF WHAT YOU’ LL DO
  • Identify, prepare and analyze novel formulations to support product development.
  • Design experiments to conduct science-based formulation optimization.
  • Evaluate the effect of each formulation component on potency, safety, stability and aerosolization.
  • Summarize results, prepare development reports, and present data to product development team.
  • Partner closely with colleagues conducting formulation evaluations, PK/PD, and in vitro and in vivo studies.
  • Provide formulations expertise and insights to various interdisciplinary teams.
  • Perform formulation transfer to process development teams and provide troubleshooting when needed

HERE’ S WHAT YOU’ LL BRING TO THE TABLE
  • Minimally a Ph.D. in chemistry, bioengineering, chemical engineering, or a related discipline with at least one year of successful laboratory experience in lipid nanoparticles or other lipid-based drug delivery systems. Comparatively, a candidate possessing an MS in chemistry, bioengineering, chemical engineering, or a related discipline with 6+ years of directly relevant experience will be considered.
  • Strong foundation in chemistry, nanotechnologies for formulation design, nucleic acid therapeutics, and general pharmaceutical product research is required.
  • Understanding of the in-vitro and in-vivo experiments used for screening for candidate formulation required.
  • Experience with process development of complex mixtures a plus.
  • Strong written and oral communication skills.
  • Comfort in a dynamic and fast-paced scientific environment
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