Scientist - III (Senior) - MA Only
Boston, MA 02115 US
Job Description
Contractor, Gene & Cell Therapy, Biologics Discovery & Engineering
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. Our company is on a quest for cures and is committed to be the worlds premier, most research-intensive biopharmaceutical company. Today, were doubling down on this goal. Our company's Research Laboratories is a true scientific research facility of tomorrow and will take our company's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. The Biologics Discovery & Engineering department in Boston, MA is seeking a contractor to support developing chimeric antigen receptor (CAR) based cell therapies. The mission of the group is to invent and develop novel gene and cell therapies to improve and save patient lives. The Gene & Cell Therapy group is part of the Discovery Biologics organization which leverages machine learning, advanced automation, ultra-high throughput in vitro and in vivo technologies, and state-of-the-art characterization methods to develop biologics. We are committed to developing new cell engineering technologies, uncovering new biology, and inventing the next wave of cell therapies to improve human health. In this role, the successful candidate will contribute directly to the invention of novel gene and cell therapies.
Responsibilities:
- Perform PBMC isolation
- Conduct cell culture to support engineering for primary T cells
- Generate genetically engineered cells by lentiviral transduction
- Support functional characterization of genetically engineered lymphocytes
- Support lab operations
- Record experimental design and results in electronic lab notebook, summarize findings and plan follow-up experiments with supervisor
• MS in a life science discipline with 1+ years or BS/BA with 2+ year post-graduate hands-on work experience in conducting lab-based research(academia/industry) or with PHD 0-1 year of relevant experience.
• Proficiency in cell culture and lentiviral transduction
• Previous experience in immune based assay (Flow cytometry, MSD, etc)
• Strong interpersonal, verbal, and written communication skills.
Software: MS office(Power Point,EXCEL, word), FlowJo
Preferred Experience and Skills:
• Familiarity with cell engineering via viral or CRISPR- based method is highly valued
• Experience in high-throughput library design and screening, viral/non-viral transgene delivery, iPSC derived immune cells, and cell line engineering are desired.
Personality:
• Must be a team player
• Detail oriented
• Focused
• Can follow protocols, SOP's and safety guidelines
• Able to communicate results to the team
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