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Scientist I/II

South San Francisco, CA 94080

Posted: 02/22/2024 Employment Type: Contract Job Category: Scientific Job Number: 597627 Is job remote?: No Country: United States

Job Description

Target PR Range: 32-56/hr
*Depending on experience

General Position Summary/Purpose:

The Quantitative Translational ADME Science (QTAS) department is seeking a highly motivated ADME/DMPK Scientist contractor (6 months) to join the In Vitro ADME Science group (Uptake Transporter Center of Excellence). The successful candidate will work in collaboration with other team members to characterize the ADME properties of candidate drug molecules. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.

In this role, you will be a scientist with hands-on experience for routinely managing mammalian cells, hepatocytes-based drug transporter assays to characterize pipeline candidate in a state-of-the art facility.

Key Accountabilities/Core Job Responsibilities:

· Routine mammalian cell culture and preservation in an efficient manner

· Handling and seeding of primary hepatocytes and recombinant cells

· Conducting HT-screening for inhibition potential on uptake transporters

· Conducting in vitro ADME/drug-drug interactions studies

· Analyzing data and maintenance of detailed, accurate and comprehensible study documentations



Education, Qualifications and Experience Requirements (degree, certifications, etc.):

· MS degree (+0 years of experience),

· B.S. (5+ years of experience) -in pharmaceutical sciences, pharmacology, biological chemistry or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development

· (Candidates with PhD/PharmD degree (0+ years of experience), MS degree (+3 years of experience)

· Excellent skills and understanding of recombinant/transiently transfected cell lines, culture, seeding, storage is must

· Working experience with hepatocytes, 2D/3D culture

· Hands-on-experience with molecular and cellular biology laboratory techniques

· Working experience with in vitro drug transporters, metabolism is a plus

· Familiarity with enzyme/transporter kinetics, data fitting

· Experience with radioisotope-based assay is a plus

· Knowledge of both biological and physicochemical properties of small molecules that influence ADME

· Experience with use of electronic lab notebook is a plus

· The individual is also expected to be organized, a team player, passionate about drug discovery, and possess effective communication skills
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