Scientist I
South San Francisco, CA 94080 US
Job Description
Target PR Range: 34-44/hr
*Depending on experience
ยท Perform routine tasks such as media/buffer preparation, thawing of cryopreserved cells, cell culture passaging, aseptic sampling and banking competently and independently to support ongoing projects in cell culture lab
ยท Take routine analytical measurements for cell growth, gas-content analysis, pH, osmolality, nutrient and metabolite measurements and HPLC analysis of monoclonal antibody titers
ยท Utilize technical expertise and available information to troubleshoot and resolve operational hurdles when encountered and adapt protocols as necessary
ยท Collaborate across CMC functions to optimize bioprocess parameters for the production of difficult-to-manufacture biologics
ยท Execute high-throughput fed batch and batch experiments and perform data analysis of the same
ยท Able to maintain a โcan-doโ attitude to complete innovative projects while being flexible in work priorities based on business needs
ยท Perform tasks with rigorous attention to detail consistently. Prioritize tasks and contribute to a highly motivated and productive team with a sense of urgency and desire to meet project timelines
ยท Accurately document, critically analyze/interpret data and communicate the results promptly through various electronic means
ยท Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials
ยท Must be comfortable with physical activities of constant standing, walking, and sitting with arm stretching into biosafety cabinets for cell culture work and occasionally lifting 50Ibs.
ยท Strong interpersonal skills to thrive in a team environment
Experience Qualifications
ยท BS in Biological Sciences or Chemical/Biochemical Engineering or related field with typically 0-3 years of industry experience; or, MS with no additional experience
ยท Prior experience in bioreactor operation and cell culture media preparation is a must
ยท Industry experience in sterile fermentation techniques preferably mammalian cell culture
ยท Experience in single use mammalian cell culture tools employed in bioprocess development, including but not limited to deep well plates, shake flasks, ambr250s, stirred tank reactors
ยท Excellent aseptic techniques and familiarity with principles of sterilization/disinfection.
ยท Familiar with general troubleshooting techniques and implementation of quality controls in developmental lab
ยท Experience with process development, optimization, and troubleshooting
ยท Experience in setting up high throughput experiments in both fed batch and batch modes, and comfortable with automation and manual operation when needed.
ยท Comfortable with practical considerations needed to successfully scale up conditions tested in high throughput systems to larger scales
ยท Excellent communication skills and experience using collaborative cloud-based technologies to in a hybrid working environment.
ยท Basic knowledge on biological data collection and analysis tools (GraphPad Prism, HPLCs, Blood gas analyzers, metabolite analyzers) and computer applications such as MS Word, MS Excel and MS PowerPoint.
ยท Able to maintain instrumentation, inventory and cleanliness of a developmental lab to create a safe, effective and efficient scientific working environment.
ยท Familiarity with the use of single use mammalian cell culture technologies such as deep well plates, shake flasks, ambr250s, stirred tank bioreactors
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