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Scientist II

Cambridge, MA 02141

Posted: 04/17/2025 Employment Type: Contract Job Category: Scientific Job Number: 618876 Is job remote?: No Country: United States

Job Description


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Job Description
The Drug Metabolism and Disposition group in QTAS has an open position for a Senior /Research Associate Scientist to perform drug metabolism/metabolite identification studies supporting a series of small molecule drug discovery projects. The selected candidate will be responsible for designing and conducting in vitro metID studies, processing the data, and interpreting MS/MS results. It is a fully drug metabolism laboratory-based role. It would be advantageous for the candidate to have practical hands-on experience performing in vitro and in vivo biotransformation studies, liquid chromatography, mass spectrometry, structure elucidation/identification, fit-for purpose analytical method development including cross-species metabolite profiling.

Responsibilities:
This role is fully lab based. Responsibilities include but not limited to:
· Perform routine soft-spot identification studies and investigational vitro studies to address specific DMPK questions in drug discovery from lead optimization to candidate selection processes
· Develop a series of analytical methods using a mass spectrometer (LC-MS/MS) to separate and detect small molecules
· Conduct in-depth analysis of Thermo Exploris 240/ QE LCMS/MS data by using Chemdraw, MassFrontier, Compound Discovere, Webmetabase platform
· Assume responsibility for maintaining laboratory equipment and maintain clear, detailed, and up-to-date experimental records
· Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department
· Conduct other duties as assigned
· Maximize the experience at one of the best places to work environment, with opportunities to network and learn from other professionals in adjacent fields

Required Qualifications:
· Bachelor`s degree in Chemistry, Analytical Chemistry, Biological Sciences and Biochemistry. or related field with at least five years of hands-on, relevant drug metabolism/met ID lab experience working with a mass spectrometer. Master’s degree in Organic Chemistry, Analytical Chemistry, Biochemistry with at least 3 years of experience.
· Hands on Lab experiences performing metabolic stability, CYP inhibition, and metabolite ID studies in liver subcellular fractions and hepatocytes preparing and analyzing samples from in vivo biological matrices using a mass spectrometer (LC-MS/MS)
· Strong consideration will be given to candidates proficient in using and troubleshooting a LC-MS/MS Thermo Exploris 240/ QE instrumentation, and handling Compound Discoverer or Webmetabase is a plus)
· Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing experiments while proactively seeking out senior personnel to discuss potential solutions to problems
· Highly motivated and able to work in a fast-paced environment with a desire to learn and tackle new challenges

The staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.

Planet Pharma is an equal opportunity employer. It is our practice not to discriminate against any employee or applicant based on any criteria, condition or basis protected by laws or regulations in the locations where we do business. All qualified applicants are encouraged to apply. We celebrate diversity and are committed to providing an environment of mutual respect. We believe that diversity, equity and inclusion enable us to better meet our mission and values while serving our clients across the globe. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter, or contact us, so that we can discuss the appropriate alternatives available.

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About Cambridge, MA

Calling all job seekers! Discover exciting job opportunities in and around Cambridge, Massachusetts, a vibrant city known for its rich history, world-renowned universities like Harvard and MIT, and innovative tech scene. Cambridge offers a unique blend of academic excellence, cultural diversity, and a thriving arts community, with attractions like the iconic Harvard Square, the charming Charles River Esplanade, and the prestigious American Repertory Theater. From savoring local specialties like clam chowder and lobster rolls to cheering on the Red Sox at Fenway Park, there's something for everyone in this dynamic region. Explore job listings today and kick-start your career in this captivating area!

Although this hasn't been an issue at Planet Pharma, the staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.