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Scientist II
South San Francisco, CA 94080 US
Job Description
Target PR Range: 50-60/hr
*Depending on experience
General Position Summary/Purpose:
The DMPK-BA department is seeking a highly motivated fulltime DMPK Scientist to join the In Vitro ADME Sciences group (IVAS). The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and also may work on other in vitro ADME assays. DMPK-BA works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays primarily including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes. Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.
Core Job Responsibilities:
· Routinely conduct (hands-on) evaluation of CYP450 induction
· Conduct qPCR assay
· Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
· Perform human hepatocytes cell culture, seeding and maintenance
· Perform cell viability assessments and use microplate reader to measure endpoint
· Contribute to invitro ADME assay design and discussions
· Analyze data and maintain detailed, accurate and comprehensible study documentations
· Use BioELN and GraphPad Prism for data analysis
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Planet Pharma is an equal opportunity employer. It is our practice not to discriminate against any employee or applicant based on any criteria, condition or basis protected by laws or regulations in the locations where we do business. All qualified applicants are encouraged to apply. We celebrate diversity and are committed to providing an environment of mutual respect. We believe that diversity, equity and inclusion enable us to better meet our mission and values while serving our clients across the globe. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter, or contact us, so that we can discuss the appropriate alternatives available.
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