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Scientist II
South San Francisco, CA 94080 US
Job Description
Target PR Range: 50-60/hr
*Depending on experience
General Position Summary/Purpose:
The DMPK-BA department is seeking a highly motivated fulltime DMPK Scientist to join the In Vitro ADME Sciences group (IVAS). The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and also may work on other in vitro ADME assays. DMPK-BA works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays primarily including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes. Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.
Core Job Responsibilities:
· Routinely conduct (hands-on) evaluation of CYP450 induction
· Conduct qPCR assay
· Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
· Perform human hepatocytes cell culture, seeding and maintenance
· Perform cell viability assessments and use microplate reader to measure endpoint
· Contribute to invitro ADME assay design and discussions
· Analyze data and maintain detailed, accurate and comprehensible study documentations
· Use BioELN and GraphPad Prism for data analysis
Equal Opportunity Employer: We are proud to be an equal opportunity employer. We welcome and encourage applications from all qualified candidates regardless of race, sex, gender identity or expression, disability, age, religion or belief, sexual orientation, or any other characteristic protected by applicable laws and regulations. It is our policy not to discriminate against any applicant or employee, and we are committed to fostering a diverse, inclusive, and respectful work environment across all locations in which we operate. We believe that diversity, equity, and inclusion are fundamental to our mission and enhance our ability to serve clients globally. If you have a disability or require any reasonable accommodations during the application or interview process, please inform your recruiter or contact us directly so that we can explore the appropriate arrangements.
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