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Screening Scientist

SOUTH SAN FRANCISCO, CA 94080

Posted: 11/28/2023 Employment Type: Direct Hire/Perm Job Category: Engineering Job Number: 590464 Is job remote?: No Country: United States

Job Description

As part of the Protein Engineering team, the Screening Scientist will advance our genetic medicine technologies, enabling the discovery and development of new therapeutics. Working with a diverse team of cell biologists, protein and RNA engineers, computational scientists, molecular biologists, and translational biologists, you will:
  • Establish pipelines for both pooled and arrayed screening of CRISPR-Cas-related and novel systems that enable therapeutic genome and transcriptome engineering
  • Develop targeted functional screens, libraries, and directed evolution experiments for these systems
  • Fully characterize and optimize our screening platform to balance library size, sensitivity, false positive rate, and other key parameters  
  • Collaborate with structural biology, computational biology, and machine learning colleagues to bias screen designs using the best available insights
  • Consider all aspects of a viable therapeutic system in your screening and selection, including efficacy, specificity, immunogenicity, delivery, etc.   
  • Remain focused on the creation of viable therapeutic products that change the lives of patients

Requirements:                                  
  • PhD in Bioengineering, Biophysics, Molecular Biology, Engineering, or related fields
  • Strong understanding of structural biology and general protein engineering methodologies
  • Experience leveraging high-throughput molecular or synthetic biology to support protein and RNA engineering
  • Experience developing functional genomic screens
  • Familiarity with NGS library preparation, sequencing, and analysis


Preferred Qualifications:                             
  • Experience deploying and/or engineering genome editing and transcriptional regulation systems (e.g. CRISPRn CRISPRi, CRISPRa, RNAi, shRNA, etc.)
  • An understanding of structural biology and general protein engineering methodologies
  • Research interests in genetic disease, immunology or neurobiology
Some proficiency in Python, R, and analysis of genome-scale data

The staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.

Planet Pharma and The Planet Group of Companies are equal opportunity employers. It is our practice not to discriminate against any employee or applicant based on any criteria, condition or basis protected by laws or regulations in the locations where we do business. All qualified applicants are encouraged to apply. We celebrate diversity and are committed to providing an environment of mutual respect. We believe that diversity, equity and inclusion enable us to better meet our mission and values while serving our clients across the globe. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter, or contact us, so that we can discuss the appropriate alternatives available.

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Although this hasn't been an issue at The Planet Group, the staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at The Planet Group.

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