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Senior Research Associate, Discovery Biology

Redwood City, CA 94063

Posted: 04/04/2024 Employment Type: Contract Job Category: Scientific Job Number: 603535 Is job remote?: No Country: United States

Job Description

The Opportunity:

Our client is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value targets in RAS-addicted cancers with our novel tricomplex inhibitor platform. We are seeking a Senior Research Associate to help the Discovery Biology team advance our discovery and development pipeline.  The successful candidate will join a high-functioning team of chemical biologists, biochemists, and cell biologists to help identify new molecules of interest, characterize compounds with novel mechanisms of action, and identify new potential targets. They will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting new biochemical and cellular assay. The ideal candidate is an open-minded and enthusiastic team player who enjoys problem solving and collaborating cross-functionally to develop novel therapeutics.

The responsibilities may include:

  • Develop and conduct mechanistic biochemical assays to characterize novel hit compounds.

  • Design and develop novel cellular assays using common cell engineering techniques such transient transfection, viral transduction, and CRISPR/Cas9 gene editing.

  • Maintain detailed and organized records of protocols and experimental results.

  • Collaborate cross-functionally with other team members to advance projects.

  • Analyze, interpret, and present experimental data in team meetings.

Required Education, Experience, and Skills:

  • BS with 5+ years of experience or MS with 3+ years of experience in Chemistry, Chemical Biology, Biochemistry, Bioengineering, or related discipline.

  • Strong understanding of protein biochemistry with hands on experience performing biochemical and biophysical assays.

  • Experience in microplate-based assay systems, and operation of plate readers or microscopes.

  • Familiarity with data processing and visualization tools for data analysis (e.g., GraphPad Prism, Genedata Screener, R, etc.).

Preferred Skills, Experience and Education:

  • Knowledge of biochemical and biophysical techniques such as surface plasmon resonance, isothermal titration calorimetry, fluorescence polarization, differential scanning fluorimetry, etc.

  • Familiarity with the following cellular and biochemical readouts including immunofluorescence, luminescence, cell viability, FRET, ELISA, MSD, flow cytometry.

  • Experience with mammalian cell culture is a plus.
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