Senior Research Associate - Translational Sciences - In Vivo Pharmacology
1150 Marina Village Pkwy Alameda, CA 94501 US
Job Description
We are seeking a highly creative, passionate, and motivated individual to join us in our quest to bring the next generation of CRISPR-based therapeutics into the IND enabling framework. The current role is for a Senior Research Associate, Translational Sciences- to join our in-vivo pharmacology team. The Research Associate will help execute our in-vivo experiments, which are critical to our efforts to develop therapeutic strategies to address the underlying cause of disease. The candidate should have a passion for working collaboratively with biologists and bioengineers to enable building the necessary tools for meeting the new frontier of CRISPR based therapeutics. Additionally, the candidate would bring expertise in rodent handling, dosing, in-life blood collection, and terminal procedures.
Key Responsibilities:
- Work closely with the in-vivo team to execute in-vivo studies to generate POC and efficacy and PK data with gene therapy candidates.
- Execute critical in-vivo procedures in rodents, especially IV tail vein dosing, in-life blood collection, necropsy and terminal blood and tissue collection and processing.
- Work with the in-vivo team in streamlining animal study execution, sample collection, and sample transfer with quality oversight
- Aid the vivarium team in maintaining and managing the vivarium as needed.
- Analyze in-vivo samples using RT-qPCR and ELISA
- Effectively collaborate with members within a fully integrated team to facilitate execution on projects with established timelines.
- Foster a driven, fast-paced, dynamic, and fun environment to do rigorous science.
- A BS/BA in Biology, or closely related field with 5+ years of lab experience in in-vivo pharmacology and/or bioanalysis in pharmaceutical environments
- 2+ year experience working with rodents, especially mice.
- Adept in IV dosing, blood collection and necropsy and tissue collection.
- Experience in wet lab techniques like RNA/DNA extraction and RT-qPCR or the ability and willingness to learn these techniques.
- Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research team.
Preferred Skills and Background:
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- Familiarity with CRISPR technologies and therapeutic approaches
- Experience running Bioanalytical assays in industry setting
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