Senior Research Associate I
45 Sidney Street Cambridge, MA 02139 US
Job Description
The candidate will gain experience interrogating cellular and molecular mechanisms as they relate to kinase target pathway modulation, off-target liabilities, and resistance. The candidate’s primary role will be lab based and include cellular assays to support drug discovery efforts. This position offers the opportunity to impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment.
Responsibilities:
- Independently conduct, optimize, and proactively troubleshoot cellular screening assays.
Main Responsibilities:
- Run cellular assays to screen small molecules in support of drug discovery efforts.
- Employ cellular and molecular techniques such as Western blotting, qPCR, ELISA, and flow cytometry to support mechanism of action studies.
- Analyze and record detailed experimental data in an electronic laboratory notebook in a timely manner.
- Actively participate in cross-functional projects.
- Present data to integrated project teams.
Education
- BS/MS in in cell/molecular biology, cancer biology, genetics, or related discipline with 1-3 years of laboratory experience in an academic or industrial setting
Basic qualifications
- Experience with mammalian cell culture, including sterile technique, transfection, and transduction techniques.
- Experience with cell-based assays in 96 and 384 well format.
- Familiarity with state-of-the-art experimental techniques and the ability to implement new technologies when applicable
- Strong organizational and communication skills
- Strong problem solving and interpersonal skills to facilitate cross-functional collaboration
- Highly self-motivated, team player, capable of adapt to fast-paced and collaborative work environment
Additional qualifications
- Previous drug discovery experience in cancer biology is a plus.
- Hands-on experience with AlphaLISA, HTRF, and IF techniques is a plus.
- Prior experience with stable cell line generation is a plus
- Prior experience with automation or HTS is a plus.
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