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Sr Research Associate/Scientist
1150 Marina Village Pkwy Alameda, CA 94501 US
Job Description
Company Summary:
Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.
Job Description
Scribe Therapeutics is seeking a candidate with experience in formulation and downstream processing of lipid nanoparticles, stability evaluation of LNPs, and in vitro and in vivo assessment of the LNP systems. The candidate will join as a SRA/Scientist with the process sciences team to develop formulations for its CRISPR by Design™ platform. The ideal candidate should have a good understanding of lipid nanoparticle formulations by various mixing and downstream processing techniques.
Key Responsibilities
- Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and intermediate scales.
- Follow SOPs and perform in-process and release analysis of manufacturing operations. Perform set-up and cleanup of equipment and manufacturing space.
- Assist team to generate LNP formulations for in-house and R&D requirements.
- Perform analysis of formulations using; UPLC-UV, UPLC-CAD, LC-MS, CGE, DLS, plate-based assays, gels, pH, osmolality, and endotoxin.
- Data analysis using statistical software’s such as GraphPad PRISM, JMP etc.,
- Effectively collaborate within various groups and map out future needs and manage procurement of materials.
- Maintain detailed records of experimental protocols and data in electronic laboratory notebook.
- Additional duties and responsibilities as required will be assigned based on the needs of the team.
- BS with 5+ years of experience, or MS/PhD with 3+ year of experience in an industry setting. Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline.
- Experience with downstream processing, such as dialysis, Tangential Flow Filtration (TFF), ultra-filtration and sterile filtration techniques.
- Experience with drug delivery and RNA are an asset.
- Excellent collaborative, communication skills and a good team player.
• Familiarity with CRISPR technologies and therapeutic approaches
- Knowledge of lipid nanoparticles, analytical characterization of lipids and nucleic acid payloads
- Ability to run methods and characterization techniques such as Particle size analysis, RNA content analysis, Osmometer, Agarose-Gel, Western Blot, UV-Vis Spectroscopy, UPLC-CAD, UPLC-UV, fragment analyzer, ELISA, 96 well plate-based assays.
- Knowledge and experience using GraphPad, JMP are preferred.
Equal Opportunity Employer: We are proud to be an equal opportunity employer. We welcome and encourage applications from all qualified candidates regardless of race, sex, gender identity or expression, disability, age, religion or belief, sexual orientation, or any other characteristic protected by applicable laws and regulations. It is our policy not to discriminate against any applicant or employee, and we are committed to fostering a diverse, inclusive, and respectful work environment across all locations in which we operate. We believe that diversity, equity, and inclusion are fundamental to our mission and enhance our ability to serve clients globally. If you have a disability or require any reasonable accommodations during the application or interview process, please inform your recruiter or contact us directly so that we can explore the appropriate arrangements.
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