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Sr Research Associate/Scientist

Alameda, CA 94501

Posted: 09/04/2024 Employment Type: Contract Job Category: Scientific Job Number: 614191 Is job remote?: No Country: United States

Job Description

Sr Research Associate/Scientist Position Description

Company Summary:
Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.
Job Description
Scribe Therapeutics is seeking a candidate with experience in formulation and downstream processing of lipid nanoparticles, stability evaluation of LNPs, and in vitro and in vivo assessment of the LNP systems. The candidate will join as a SRA/Scientist with the process sciences team to develop formulations for its CRISPR by Design™ platform. The ideal candidate should have a good understanding of lipid nanoparticle formulations by various mixing and downstream processing techniques.
Key Responsibilities
  • Formulate and characterize lipid nanoparticle (LNPs) formulations both at small and intermediate scales.
  • Follow SOPs and perform in-process and release analysis of manufacturing operations.  Perform set-up and cleanup of equipment and manufacturing space.
  • Assist team to generate LNP formulations for in-house and R&D requirements.
  • Perform analysis of formulations using; UPLC-UV, UPLC-CAD, LC-MS, CGE, DLS, plate-based assays, gels, pH, osmolality, and endotoxin.
  • Data analysis using statistical software’s such as GraphPad PRISM, JMP etc.,
  • Effectively collaborate within various groups and map out future needs and manage procurement of materials.
  • Maintain detailed records of experimental protocols and data in electronic laboratory notebook.
  • Additional duties and responsibilities as required will be assigned based on the needs of the team.
Required skills and background:
  • BS with 5+ years of experience, or MS/PhD with 3+ year of experience in an industry setting. Degree in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, or related discipline.
  • Experience with downstream processing, such as dialysis, Tangential Flow Filtration (TFF), ultra-filtration and sterile filtration techniques.
  • Experience with drug delivery and RNA are an asset.
  • Excellent collaborative, communication skills and a good team player.
Preferred Skills:
•     Familiarity with CRISPR technologies and therapeutic approaches
  • Knowledge of lipid nanoparticles, analytical characterization of lipids and nucleic acid payloads
  • Ability to run methods and characterization techniques such as Particle size analysis, RNA content analysis, Osmometer, Agarose-Gel, Western Blot, UV-Vis Spectroscopy, UPLC-CAD, UPLC-UV, fragment analyzer, ELISA, 96 well plate-based assays.
  • Knowledge and experience using GraphPad, JMP are preferred.

The staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.

Planet Pharma and The Planet Group of Companies are equal opportunity employers. It is our practice not to discriminate against any employee or applicant based on any criteria, condition or basis protected by laws or regulations in the locations where we do business. All qualified applicants are encouraged to apply. We celebrate diversity and are committed to providing an environment of mutual respect. We believe that diversity, equity and inclusion enable us to better meet our mission and values while serving our clients across the globe. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter, or contact us, so that we can discuss the appropriate alternatives available.

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About Alameda, CA

Ready to kickstart your career in the vibrant and thriving area around Alameda, California? This picturesque region, nestled in the San Francisco Bay Area, offers an abundance of job opportunities with a backdrop of stunning views and a rich cultural scene. Discover the charm of Alameda with its historic landmarks like the USS Hornet Museum, unique cuisine at Alameda's vibrant restaurants, and diverse entertainment options at venues like the Alameda Theatre & Cineplex. With easy access to outdoor activities at Crown Memorial State Beach and the Alameda Marina, this area provides the perfect blend of work and play. Explore our job listings today and make your mark in this enchanting location!

Although this hasn't been an issue at Planet Pharma, the staffing industry has seen an increase in people falsely representing themselves as recruiters to gather personal information from job seekers. For your safety, do not provide sensitive data to anyone you have not spoken with thoroughly and never provide banking information during the application process. Candidate safety is a top priority at Planet Pharma.