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Sr. RA, In vivo Pharmacology

South San Francisco, CA 94080

Posted: 04/10/2025 Employment Type: Contract Job Category: Scientific Job Number: 618854 Is job remote?: No Country: United States

Job Description

Duties:    
KEY ROLE AND RESPONSIBILITIES:
  • Proficient in basic animal handling, including blood sample collection and necropsy with organ/tumor sample collection.
  • Setup and execution of in vivo studies using xenograft and syngeneic mouse models of solid tumors including animal preparation/surgery, tumor implantation (s.c., i.p., i.v., or orthotopic), preparation and dosing of therapeutic T cells and other agents via various routes of administration, tracking of tumor growth (eg., bioluminescence/fluorescence, micro-CT, and caliper measurements), collection of blood, tissue, tumor samples, and monitoring of animal health.
  • Maintenance of a highly functioning in vivo and ex vivo labs, working with the other members of the In Vivo Pharmacology group and other cross-functional scientists.
  • Ex vivo study responsibilities include cell culture, collection and processing of organs and tumor samples for immunological and pathological analysis.
  • Collection, entry, analysis, and presentation of study data to project teams
  • Generation and maintenance of electronic lab notebook (ELN) reports, including basic statistical data analysis.
PREFERRED EDUCATION:
  • BSc. in biotechnology, molecular biology, microbiology, immunology, oncology or related field with a minimum of 7 years’ experience within the area of focus; or
  • MSc. in biotechnology, molecular biology, microbiology, immunology, oncology or related field with a minimum of 5 years’ experience within the area of focus;
PREFERRED EXPERIENCE:
  • Proficient in executing various xenograft and syngeneic tumor models using immunocompromised (NSG-MHCI/II-dKO) and immune-competent mice with adoptive T cell transfer
  • Proficient with mammalian cell culture techniques such as cell line passaging, cryopreservation and cell thawing, and cell counting.
  • Proficient using and analyzing high-parameter flow cytometry
KNOWLEDGE, SKILLS AND ABILITIES:
  • Data analysis using software packages (FlowJo, FCS Express, Prism)
  • Experience using and analyzing common immunology and oncology related to the specific project; cell therapy experience is ideal, more complex experience a plus
  • Proficient in sterile tissue culture technique and experience working with human cells
  • Experience with flow cytometry assays and analysis; more complex analysis and cell sorting experience a plus
  • Experience in data production and reporting for IND-enabling studies
  • Additional specific experience related to the area of focus may be required



Pay Rate Range: $50-64/hr depending on experience 
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