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Sr. Research Associate - Cancer Immunology

Redwood City, CA 94063

Posted: 02/19/2024 Employment Type: Contract Job Category: Scientific Job Number: 599471 Is job remote?: No Country: United States

Job Description


Sr. Research Associate  - Cancer Immunology 

Our Client is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a key member of our dynamic Biology team, you will have proven expertise in:

  • Mammalian cell culture.

  • Flow cytometry, including cell staining, processing, and data analysis.

  • Cell-based assay development using reagent kits, including but not limited to SDS PAGE/Western blot, ELISA, ELISpot, MSD, DNA/RNA extraction, PCR, RTqPCR.

  • Plate-based assays – including automation (comfortable using robotics for compound dilutions, additions), plate washers, plate readers, multichannel pipettes.

  • Excellent team member, collaborator, and communicator, eager to learn new techniques

  • Additional experience in the following a plus:

  • Immuno-oncology assays such as T cell proliferation, suppression and killing assays, antigen presentation assays, phagocytosis assays, etc.

    • Experience with primary immune cells, including human PBMC handling, isolation and differentiation.

    • Incucyte cell-based assays.

    • Ex vivo experiments, including murine tissue collection, dissociation, and processing for downstream applications.

Required Experience, Skills, and Education:

  • Bachelor’s degree or Master’s degree in Science with 3+ years of experience in a cell biology/cellular assay development role. Title will be adjusted according to experience.

  • Deep expertise with mammalian cell culture across a variety of cell types (primary and immortalized) and growth conditions. Demonstrated experience handling (maintaining, passaging, plating) multiple cell lines at once.

  • Hands-on experience with a wide range of cellular assay techniques (including, but not limited to, Flow Cytometry, Western Blot, MSD, qPCR) suitable for target identification and/or compound characterization.

  • Immuno-oncology related experience is a plus.

  • Rigorous, quantitative, attention to detail, keen to maximize efficiency.

  • Highly organized, and excellent record keeping skills.

  • Excellent written and verbal communication skills to facilitate collaboration with project and departmental teams.

  • Innovative, proactive team-player with high energy who will thrive in our fast-paced drug discovery and development environment.

Requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. 
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