Sr. Research Associate - Cancer Immunology
700 Saginaw Drive Redwood City, CA 94063 US
Job Description
Sr. Research Associate  - Cancer ImmunologyÂ
Our Client is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
As a key member of our dynamic Biology team, you will have proven expertise in:
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Mammalian cell culture.
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Flow cytometry, including cell staining, processing, and data analysis.
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Cell-based assay development using reagent kits, including but not limited to SDS PAGE/Western blot, ELISA, ELISpot, MSD, DNA/RNA extraction, PCR, RTqPCR.
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Plate-based assays – including automation (comfortable using robotics for compound dilutions, additions), plate washers, plate readers, multichannel pipettes.
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Excellent team member, collaborator, and communicator, eager to learn new techniques
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Additional experience in the following a plus:
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Immuno-oncology assays such as T cell proliferation, suppression and killing assays, antigen presentation assays, phagocytosis assays, etc.
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Experience with primary immune cells, including human PBMC handling, isolation and differentiation.
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Incucyte cell-based assays.
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Ex vivo experiments, including murine tissue collection, dissociation, and processing for downstream applications.
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Required Experience, Skills, and Education:
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Bachelor’s degree or Master’s degree in Science with 3+ years of experience in a cell biology/cellular assay development role. Title will be adjusted according to experience.
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Deep expertise with mammalian cell culture across a variety of cell types (primary and immortalized) and growth conditions. Demonstrated experience handling (maintaining, passaging, plating) multiple cell lines at once.
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Hands-on experience with a wide range of cellular assay techniques (including, but not limited to, Flow Cytometry, Western Blot, MSD, qPCR) suitable for target identification and/or compound characterization.
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Immuno-oncology related experience is a plus.
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Rigorous, quantitative, attention to detail, keen to maximize efficiency.
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Highly organized, and excellent record keeping skills.
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Excellent written and verbal communication skills to facilitate collaboration with project and departmental teams.
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Innovative, proactive team-player with high energy who will thrive in our fast-paced drug discovery and development environment.
Requires that all personnel and visitors to its offices be fully vaccinated against COVID-19.Â
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