Sr. Scientist, Genome Engineering
Dallas, TX 75001 US
Job Description
Duties/Responsibilities:
- Design, innovate and iterate: DNA assembly, integration, editing and screening
- Build enabling molecular and cellular tools
- Perform DNA/RNA transfections and/or viral transductions
- Quantify genome editing events using various molecular assays
- Improve the state of the art in CRISPR-guided precision genome editing
- Data analysis, figure generation and timely reporting of results
- Present findings at small forums and R&D meetings
- Maintain a thorough and detailed electronic lab notebook
- Maintain a clean and organized laboratory space
- PhD/MS in synthetic biology, bioengineering, molecular biology, genetics or related field is required, or 3+ years hands-on expertise in genetics and genomic manipulation
- Solid understanding and hands-on experience with current precision editing techniques, covering the design, optimization and verification of edits made with CRISPR-Cas9/HDR, Base Editors, nicking-based methods, or large construct integration methods
- Experience with cell culture, DNA/RNA transfection, bacterial culture, recombinant DNA cloning techniques, primer design and PCR, gel electrophoresis, nucleic acid extraction and purification
- Self-motivated, proactive, works well under pressure and deadlines, detail-oriented
- Enthusiasm for learning new skills and taking on new responsibilities
- Strong written and oral communication skills, as well as creative problem-solving skills
- Enjoys the fast-paced startup environment and teamwork
- High throughput screening experience or automation methods
- NGS library prep, immunostaining or flow cytometry experience
- Animal tissue culture experience
- Current experience with next-generation, precision editing tools
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