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Sr. Scientist, Genome Engineering

Dallas, TX 75001

Posted: 06/01/2023 Employment Type: Direct Hire/Perm Job Category: Scientific Job Number: 558166 Is job remote?: No Country: United States

Job Description

  • Design, innovate and iterate: DNA assembly, integration, editing and screening
  • Build enabling molecular and cellular tools
  • Perform DNA/RNA transfections and/or viral transductions
  • Quantify genome editing events using various molecular assays
  • Improve the state of the art in CRISPR-guided precision genome editing
  • Data analysis, figure generation and timely reporting of results
  • Present findings at small forums and R&D meetings
  • Maintain a thorough and detailed electronic lab notebook
  • Maintain a clean and organized laboratory space
Basic Qualifications:
  • PhD/MS in synthetic biology, bioengineering, molecular biology, genetics or related field is required, or 3+ years hands-on expertise in genetics and genomic manipulation
  • Solid understanding and hands-on experience with current precision editing techniques, covering the design, optimization and verification of edits made with CRISPR-Cas9/HDR, Base Editors, nicking-based methods, or large construct integration methods
  • Experience with cell culture, DNA/RNA transfection, bacterial culture, recombinant DNA cloning techniques, primer design and PCR, gel electrophoresis, nucleic acid extraction and purification
  • Self-motivated, proactive, works well under pressure and deadlines, detail-oriented
  • Enthusiasm for learning new skills and taking on new responsibilities
  • Strong written and oral communication skills, as well as creative problem-solving skills
  • Enjoys the fast-paced startup environment and teamwork
Preferred Qualifications:
  • High throughput screening experience or automation methods
  • NGS library prep, immunostaining or flow cytometry experience
  • Animal tissue culture experience
  • Current experience with next-generation, precision editing tools

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