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Technical Development Scientist

S San Francisco, CA 94080

Posted: 05/23/2024 Employment Type: Contract Job Category: Scientific Job Number: 606703 Is job remote?: No Country: United States

Job Description

Job title: Technical Development Scientist

Technical Development Scientist Job Knowledge & Scope RMG, in the Cell Culture and Bioprocess Operations department, is responsible for providing support to pre-Early Stage Research to Early Development projects with high-throughput protein production from mammalian transient cultures. We are looking for a motivated candidate with cell culture and sterile technique experience to join our team to enable protein production at Genentech and help advance our portfolio.

Key Responsibilities
  • Perform transient transfections in CHO and HEK293 cells in scales 1mL to 25L to support pipeline productions adhering to established protocols
  • Maintain seed train cell cultures in bioreactors and shake flasks
  • Operate liquid handlers - Tecan and Hamilton for automated processes
  • Operate wave bag reactors for productions and cell maintenance
  • Maintain and troubleshoot key cell culture instruments such as Vi-Cell, Nova Flex2, Nova Flex, Cedex and bioreactors
  • Participate in troubleshooting production or platform processes
  • Participate in lab management and data management.
  • Contribute to improving existing cell culture platforms and developing new platforms to deliver diverse protein and cellular reagents to enable a large number of research programs.

The candidate must be highly self-motivated, organized, detail oriented and responsive to feedback. The candidate is expected to precisely follow written procedures, practice sterile technique, demonstrate accurate documentation skills, and report deviations in a timely manner. They should be able to work independently within guidelines and policies, with minimal guidance. Qualifications Required:
  • PhD (with 0-2yrs relevant experience) in Biotechnology, Chemistry, Biochemistry or related fields
  • Suspension adapted mammalian cell culture (CHO and/or HEK293)
  • Excellent written and verbal communication skills, and have strong collaborative skills.

  • State-of-the-art transient and stable protein expression experience
  • Relevant bioreactor experience
  • Hands-on experience with automation and liquid handlers like Tecan Freedom Evo and Hamilton Microlab Star
  • Knowledge of cell biology, cell engineering, molecular biology, recombinant protein purification and protein characterization is preferred 

Pay Rate Range: $50-60/hr. Salary will be commensurate with experience 
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