Job Details

Senior Research Associate, Cancer Immunology

The Opportunity:

As a key member of our Cancer Immunology team in this lab-based role, you will serve as the primary point of contact for flow cytometry operations – responsible for the following:

• Managing flow cytometer instruments:

• • Perform daily startup, quality control (QC), routine maintenance, and performance verification of flow cytometers and cell sorter.

  • Troubleshoot instrument issues and coordinate repairs and preventative maintenance with external vendors as needed.

  • Maintain inventories of instrument consumables and reagents.

• Performing routine flow cytometry assays.

• • Execute sample preparation and acquisition workflows, including sample handling, processing, and staining, in compliance with established SOPs.

  • Perform antibody titrations to optimize staining conditions for new and existing panels, and support spectral panel optimization, including fluorophore selection and spectral unmixing.

  • Perform data acquisition and analysis.

  • Optimize sample preparation, staining, and acquisition methods.

• Providing technical support.

• • Train new users on instrument startup, QC procedures, sample acquisition, and best laboratory practices.

  • Assist scientists with experimental design and flow cytometry workflows.

  • Develop and maintain standard operating procedures (SOPs) for instrument operation and flow cytometry assays.

  • Manage flow cytometer instrument data, including storage, backup, and export of flow cytometry files.

  • Monitor and evaluate emerging flow cytometry technologies, reagents, and workflows to maintain up-to-date knowledge of novel dyes, fluorochromes, instrumentation, and assay standards.

  • Manage flow cytometry core calendaring.

Required Skills, Experience and Education:

• Bachelor’s degree or Master’s degree in Science with 3+ years of experience in a cell biology/cellular assay development role. Title will be adjusted according to experience.

• Deep expertise with multi-color spectral flow cytometry assays.

• High proficiency in designing high-parameter flow panels and running experiments independently, including sample handling, cell staining, and data acquisition and analysis.

• Highly organized and proactive, with a demonstrated ability to identify opportunities to improve laboratory workflows and operational efficiency.

• Rigorous and quantitative approach, strong attention to detail, and excellent record-keeping skills.

• Excellent written and verbal communication skills to facilitate collaboration with project and departmental teams.

• Innovative, proactive team player who thrives in a fast-paced drug discovery and development environment.

Preferred Skills:

• Prior experience as a Flow Cytometry core manager.

• Prior experience working with Cytek Aurora flow cytometer and SH800S sorter.

• Hands-on experience with primary immune cells, including human PBMC handling, isolation and differentiation.

• Immuno-oncology assays including immune cell phenotypic and functional characterization by flow cytometry (T cell proliferation, suppression and killing assays, antigen presentation assays, phagocytosis assays, etc.).

• Prior experience utilizing electronic laboratory notebooks.