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Research Associate, Mol Bio & Cell-based Assay, Analytical Development
South San Francisco, CA 94080 US
Job Description
Gene Therapies is a Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Center of Excellence for their newly created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach. We are based in San Francisco.
The Role
The Research Associate will work closely with the Analytical Development team in the Tech Dev department to help methods development and test samples utilizing PCR, ELISA, Gel Electrophoresis, cell-based and other assays; as well as to contribute to design and performing experiments with supervision as needed; complete assigned tasks within time frames with high quality; maintain a well-documented record of activities in ELN and reports.
Additionally, the role includes regularly summarizing and presenting experimental results in meetings and participating in report writing. Work in a collaborative, hypothesis-driven laboratory environment. The position level will be commensurate with education and experience level. This role will be at our South San Francisco R&D facility.
Primary Responsibilities
• Develop, optimize and execute analytical assays for proteins, DNA, adeno associated viral (AAV) nanoparticles and related cell-based assay.
• Perform routine testing using established SOPs and applicable regulatory guidelines, including but not limited to ddPCR/qPCR, ELISA, and mammalian cell-based assays.
• Support assay transfer to internal partners (QC, testing, and research teams), including documentation, troubleshooting, and method comparability.
• Analyze experimental data, assess data quality, and determine applicability to project goals; draw conclusions and make data-driven recommendations.
• Author, review, and revise experimental procedures, protocols, and technical reports.
• Maintain accurate, timely, and compliant records of all analytical development activities in laboratory notebooks and data systems.
• Contribute to a collaborative laboratory environment by sharing technical insights, supporting cross-functional projects, and continuously improving workflows.
About you
Must-Have/Required
• B.S. in Biology, Biochemistry, Molecular Biology, or a related discipline, with 1+ years of industry experience in pharmaceutical or biotechnology settings.
• Demonstrated proficiency with mammalian cell-based assays and PCR-based assays (qPCR, ddPCR)
• Hands-on experience performing quantitative assays (e.g. ELISA), for the characterization of proteins, nucleic acids, viruses or other biological products.
• Strong hands-on experience with sterile technique and mammalian cell culture, including cell maintenance, expansion, characterization, and banking.
• Working knowledge of core molecular biology techniques (DNA/RNA/protein isolation, cDNA synthesis, RT-PCR, qPCR, digital PCR).
• Ability to independently plan, execute, and document experiments, while thriving in a collaborative, fast-paced team environment.
• Strong analytical thinking with attention to detail and a commitment to generating high-quality, reproducible data.
• Demonstrated ability to troubleshoot assays and propose experimental improvements. Comfort with interpreting unexpected results and recommending next steps.
• Excellent written and verbal communication skills, with the ability to clearly present technical data to both technical and non-technical audiences.
• Proficiency with Microsoft Office and standard data analysis and documentation tools.
May Have/Preferred
• Experience working with Adeno-Associated Virus (AAV)
• Experience in analytical method development and assay transfer
• Experience in basic statistical analysis
Equal Opportunity Employer: We are proud to be an equal opportunity employer. We welcome and encourage applications from all qualified candidates regardless of race, sex, gender identity or expression, disability, age, religion or belief, sexual orientation, or any other characteristic protected by applicable laws and regulations. It is our policy not to discriminate against any applicant or employee, and we are committed to fostering a diverse, inclusive, and respectful work environment across all locations in which we operate. We believe that diversity, equity, and inclusion are fundamental to our mission and enhance our ability to serve clients globally. If you have a disability or require any reasonable accommodations during the application or interview process, please inform your recruiter or contact us directly so that we can explore the appropriate arrangements.
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