In Vivo Scientist, Oncology/Immunology

South San Francisco, CA 94080

Posted: 03/30/2026 Employment Type: Direct Hire/Perm Job Category: Scientific Job Number: 626456 Is job remote?: No Country: United States

Job Description

Primary Responsibilities
    • Design and execute preclinical in vivo studies in collaboration with discovery and data scientists, develop timelines and action plans to meet company goals.
    • Choose appropriate in vivo models and develop protocols with relevant endpoints for evaluating the mechanism of action, efficacy, and safety of therapeutic candidates.
    • Perform hands-on in vivo experiments, including orthotopic tumor cell implantation, IV, IP and SC injections, in vivo imaging, and animal welfare monitoring.
    • Perform biological sample collection and processing, MACS/FACS cell sorting, immune cell profiling using multicolor flow cytometry, immunogenicity testing using ELISA and ELISPOT, and cell-based functional assays.
    • Generate, document, analyze and interpret experimental data to support critical decisions.
    • Manage external laboratories and partners.
Required Skills & Qualifications
    • PhD in Life Sciences with specialization in oncology or immunology.
    • At least 3 years of hands-on experience working with murine tumor models in an
    • industry and/or academic setting.
    • Demonstrated independent ability to design, execute and interpret experimental data.
    • Demonstrated experience in in vivo procedures, such as rodent surgery and IV dosing.
    • Experience with tissue handling and processing, cell sorting, multi-color flow cytometry and cytokine profiling, experience with IHC and ISH is a plus
    • Proficiency in mammalian cell and tissue culture.
    • Detail-oriented, with strong organizational and record-keeping skills.
    • Excellent communication skills and ability to collaborate effectively in a cross-functional team.
    • Experience working in a GLP or regulatory-compliant environment is a plus.
 
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